There are many benefits of using recombinant antibodies. Some of them are Improved reproducibility and control: While researchers with hybridoma-based systems often lose control of the antigen after being injected into the host, the production of recombinant antibodies allows them greater control of the antigen.
Because rAbs are defined by the order in which they are encoded, they are more reliable and provide more reproducible results than mAbs. By adjusting experimental conditions, researchers can easily support the isolation of antibodies against antigens or antigenic properties.
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Reduced production time: Using recombinant antibody technology, antigen-specific antibodies can be produced in as little as eight weeks. On the other hand, hybridoma technology requires at least four months to produce the appropriate antibodies.
Isotype Conversion: The desired recombinant antibody fragment can be easily converted to another species, isotype or subtype by adding the appropriate constant domain. This makes it easier to switch antibodies to the preferred format.
Animal-free technology: Recombinant antibodies can be produced without the use of animals. This eliminates many of the ethical and animal welfare issues often associated with traditional monoclonal antibody production.